Endurance SportsEpigeneticsHealthLongevityThe Daily Grist

CO2 Endurance

Life begins and ends at the cellular level.

​Lifestyles are determined by habit. The most insidious aspect of habit is its ability to dull awareness. This is when the mayhem begins…

Carbon Dioxide → CO₂

Training load is a measure of workout intensity, while CO2 tolerance refers to the body’s ability to handle high levels of carbon dioxide.

Increasing CO2 tolerance through techniques like breath-holding and controlled breathing can improve athletic performance by making the respiratory system more efficient and increasing fatigue resistance. 

Training load helps coaches and athletes manage intensity and recovery related to CO2 production. Training load is a measure of exertion and its impact on the body.

Physiological metrics such as EPOC [excess post-exercise consumption] represent one example of managing the intensity of exertion.

Hypercapnia [aka hypercarbia] is a condition in which too much CO2 is in the blood because the body does not flush it efficiently through breathing.

This accumulation occurs when CO2 production exceeds removal, often due to respiratory issues such as COPD [chronic obstructive pulmonary disease] or conditions causing hypoventilation. It can lead to acid-base imbalance [respiratory acidosis] and cause symptoms like headaches, confusion, shortness of breath, and fatigue.

CO2 and lactate are both critical during high-intensity training: CO2 aids circulation and buffers acidity, while lactate serves as a fuel source. Training at high CO2 levels improves the body’s ability to handle acidity, boosts stamina, and enhances oxygenation.

Training to improve the lactate threshold increases endurance and performance at higher speeds. Both processes are essential for improving performance and helping the body better tolerate high-intensity exercise. Training load and CO2 are directly linked because exercise produces CO2, which triggers breathlessness.

Training your body to tolerate higher CO2 levels improves endurance, delays fatigue, and enhances mental focus by optimizing oxygenation and buffering blood acidity. Specific breathing techniques recalibrate the respiratory system.

CO2 Tolerance and Training Load

→ Efficient breathing;
→ Improved lactate threshold;
→ Improved performance;
→ Circulation and buffering;
→ Enhanced CO2 tolerance;
Acidosis & buffering;
→ Increased stamina and reduced fatigue;
→ Improved lactate buffering;
→ Increased production;
Breathing response

CO2 is crucial for endurance sports, acting beyond a waste product; it improves oxygen delivery to muscles [Bohr effect], enhances blood flow, buffers acid [lactic acid], and supports muscle adaptation [fiber type]. 

It helps manage breathing effort, with higher CO2 tolerance leading to better endurance, faster recovery, and increased VO2 max by making oxygen more accessible when needed. 

Benefits of CO2 for Endurance Performance

→ Improved oxygenation;
→ Vasodilation;
→ Enhanced buffering;
→ Nervous system regulation;
→ Swift recovery;
→ Reduced fatigue;
Metabolic efficiency;
→ Acid buffering;
→ Breath control;

CO2 is crucial for regulating blood pH and oxygen release from hemoglobin, with excess levels (hypercapnia) posing respiratory issues and hypoventilation from CNS injury, requiring breathing retraining to restore balance for better oxygenation.

 It is a byproduct of metabolism, transported to the lungs, and its balance is key to nervous system function. Adequate levels calm the body and modulate conditions like breathing pattern disorders [BPDs].

Key Roles of CO2

→ pH regulation;
→ Oxygen release;
→ Respiratory drive;
→ Nervous system

The role of CO2 in respiratory physiology explains how breathing patterns impact oxygenation and the nervous system.

Potential Impact | CO2 Endurance Performance 

Bohr Effect;
Vasodilation;
→ Buffering;
→ Muscle adaptations;
→ Ventilation;
Dyspnea;
→ Reduced performance;
Hypercapnic warm-up;
CO2 tolerance training

PPARGC1a | PGC1a | PG-1

PGC-1α [Peroxisome proliferator-activated receptor gamma coactivator 1-alpha] is a master regulator protein essential for endurance sports performance. The foregoing acronyms represent the same gene.

It is a key signal for muscle adaptation to endurance exercise. Specific gene variants [the G allele] are also linked to natural athletic potential. 

CO2 production is a byproduct of this efficient aerobic metabolism, reflecting the high oxygen utilization [V̇o2 max] PGC-1α promotes, directly linking the gene to better aerobic fitness and endurance sports prowess.

PPARGC1A Endurance Influence

Mitochondrial Biogenesis;
→ Muscle fiber type;
→ Oxidative metabolism;
→ Angiogenesis;
→ Metabolic flexibility;
→ Mitigates fatigue;
→ Aerobic respiration;
V̇o2 max;
→ Performance marker

PPARGC1A builds the cellular machinery for aerobic endurance, and the resulting enhanced metabolic activity produces more CO2 as a sign of peak efficiency, linking the gene, CO2, and superior endurance performance.

The insatiable quest for peak endurance performance has led to alternative strategies and training methodologies to enhance an athlete’s capabilities.

One method that has recently gained traction is CO2 tolerance training. This technique focuses on an athlete’s tolerance for higher levels of CO2 in the body, which can have profound effects on performance. 

CO2 Tolerance Physiology

CO2 tolerance refers to the body’s ability to withstand high levels of carbon dioxide without experiencing discomfort or a drop in performance. During intense physical activity, the body produces CO2 as a byproduct of metabolism.

Efficiently handling this increased CO2 load is crucial for maintaining optimal performance. Elevated CO2 levels in the blood indicate a decrease in pH, making the blood acidic. The body’s natural response is to increase breathing rate to expel excess CO2 and restore pH balance. 

This response can sometimes lead to hyperventilation, decreasing CO2 levels, and hindering oxygen delivery to tissues.

Training to tolerate higher CO2 levels can help athletes better manage their breathing and maintain a more stable internal environment during intense exercise. This involves exercises that condition the respiratory system and the body’s overall buffering capacity.

Benefits of CO2 Tolerance

→ Improved respiratory efficiency
→ Enhanced aerobic capacity
→ Increased mental fortitude
→ Optimized oxygen utilization
→ Swift recovery
→ Enhanced endurance;
→ Improved resilience;
→ Regulated breathing;

CO2 Tolerance Techniques

Endurance athletes incorporate CO2 tolerance training into their routines through specific breathing exercises and protocols.

Techniques such as breath-hold exercises, controlled hypercapnic training (breathing in higher CO2 environments), and CO2 tolerance tests can help build the desired adaptations.

Nasal breathing;
→ Controlled breath-hold exercises;
→ Resting breath-hold exercises;
→ Hypercapnic training;
→ CO2 tables;
→ Walking breath holds;
→ Max Breath holds;
“Air Hunger” training;
Controlled & slowed breathing;
→ Sport-specific training;
Training masks
→ Gradual progression and consistency

Growth has no endpoint…

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Jeff Kildahl

Jeff Kildahl is a writer, author, researcher, and publisher leveraging technology to transcend health, performance, and longevity in life and sport. Performance Medicine™ is a visionary consulting firm providing ultra-endurance coaches and athletes with synergistic solutions to master the difference between effort and struggle. He merges the highly-specialized modalities of blood analysis, biological age, HRV, mitochondrial efficiency, and genomic sequencing with tailored guidance to optimize health, performance, and longevity in life and sport. Kildahl is credentialed in bioenergetics, biomechanics, metabolic efficiency™, endurance sports nutrition, neuromuscular physiology, and natural medicine. He is a dynamic member of CUBE™ ~ a professional speakers group ~ empowering others to harmonize the "Keys to Living in the Song of Life." His company sponsors the spirited initiatives and global events of the United States Snowshoe Association, the World Snowshoe Federation, the American Trail Running Association, the United States Trail Running Conference, and other innovative ventures. He is the publisher of SYNERGY™ | Performance Medicine™ Magazine - a cutting-edge publication designed to impart the innovative principles of Performance Medicine™. Kildahl is the creator and president of Performance Medicine™ → https://pmsynergy.com.

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